MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 50 region
نویسندگان
چکیده
Allison C Mallory, Brenda J Reinhart, Matthew W Jones-Rhoades, Guiliang Tang, Phillip D Zamore, M Kathryn Barton* and David P Bartel* Whitehead Institute for Biomedical Research, Cambridge, MA, USA, Department of Plant Biology, Carnegie Institution of Washington, Stanford, CA, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA
منابع مشابه
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region.
MicroRNAs (miRNAs) are approximately 22-nucleotide noncoding RNAs that can regulate gene expression by directing mRNA degradation or inhibiting productive translation. Dominant mutations in PHABULOSA (PHB) and PHAVOLUTA (PHV) map to a miR165/166 complementary site and impair miRNA-guided cleavage of these mRNAs in vitro. Here, we confirm that disrupted miRNA pairing, not changes in PHB protein ...
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تاریخ انتشار 2004